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All Diagnostics
Emerging DiagnosticMetabolic Health
Methylation Panel
Decode the master biochemical process behind detox, mood, and DNA repair
$300–$500
10–14 business days
Methylation panel testing measures key markers in the methylation cycle — homocysteine, SAMe, SAH, methylmalonic acid, and B-vitamin cofactors — revealing how efficiently your body is performing this critical biochemical process that affects detoxification, neurotransmitter production, DNA repair, and gene expression.
Methylation is arguably the most important biochemical process in your body. It's required for making neurotransmitters, detoxifying chemicals and hormones, repairing DNA, and controlling gene expression. When methylation is impaired, everything suffers.
What It Measures
Homocysteine (methylation bottleneck marker)
SAMe (S-adenosylmethionine — primary methyl donor)
SAH (S-adenosylhomocysteine)
SAMe-to-SAH ratio (methylation capacity)
Methylmalonic acid (B12 functional marker)
Formiminoglutamic acid (FIGLU — folate marker)
B6, B12, and folate cofactor levels
Why Gabriel Recommends It
Methylation dysfunction is at the root of countless chronic health issues: depression (can't make serotonin), fatigue (mitochondrial dysfunction), high homocysteine (cardiovascular risk), poor detoxification (can't clear estrogen or toxins), and accelerated aging (impaired DNA repair). Gabriel uses methylation panel data to identify bottlenecks in your methylation cycle and to design targeted protocols with methylated B vitamins (methylfolate, methylcobalamin), methylation cofactors (magnesium, zinc, choline), and methylation support nutrients (TMG, betaine) — personalized to your biochemistry.
What to Expect
A fasting blood draw at a local lab or specialty lab. Fast for 10–12 hours (water only). Avoid methylated B-vitamin supplements for 3–5 days before testing for baseline accuracy. Results arrive in 10–14 business days with detailed methylation cycle analysis. Upload to Gabriel for methylation optimization protocols.
How Gabriel Interprets This
Conventional practitioners read these results through a disease-focused lens — looking for what's broken. Gabriel reads them through a naturopathic lens — looking for what's out of balance and how to restore it. We see optimal ranges, not just "normal" ranges. We connect findings across all your diagnostics to reveal patterns that siloed specialists miss.
Related Conditions
Where to Get Tested
$300–$500
