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160 evidence-based supplements with mechanisms, dosing, interactions, and clinical applications
Mechanism:
Anti-inflammatory via prostaglandin/leukotriene modulation; supports brain, heart, joint, and eye health
Primary Applications:
Cardiovascular disease; Depression; ADHD; Arthritis; Dry eyes; Cognitive decline
Essential for DNA synthesis, red blood cell formation, myelin production, homocysteine metabolism
Pernicious anemia; Neuropathy; Fatigue; Depression; Cognitive decline; Vegetarian/vegan
Hormone precursor regulating calcium absorption, immune modulation, gene expression via VDR activation
Osteoporosis; Rickets; Immune deficiency; Depression; Autoimmune disease; Cancer prevention
Cofactor for 300+ enzymes; supports energy production, nerve function, muscle relaxation, sleep; glycine enhances GABA
Insomnia; Anxiety; Muscle cramps; Migraines; Hypertension; Constipation; Arrhythmias
Anti-inflammatory via COX/LOX inhibition and NF-κB modulation; antioxidant, neuroprotective
Arthritis; Inflammation; Alzheimer's prevention; Depression; Metabolic syndrome; Cancer adjunct
Methyl donor for DNA synthesis, homocysteine metabolism, neurotransmitter production; essential for cell division
Anemia; Neural tube defects; Depression; High homocysteine; Cognitive decline; Pregnancy
Mitochondrial electron transport chain cofactor; antioxidant; essential for ATP production; supports heart, brain, energy
Heart failure; Statin side effects; Hypertension; Mitochondrial disease; Fatigue; Aging
Glutathione precursor; mucolytic agent; antioxidant; supports detoxification and respiratory health
COPD; Bronchitis; Acetaminophen overdose; Addiction; OCD; Detoxification; Liver support
Antioxidant, collagen synthesis cofactor, immune support, enhances iron absorption, regenerates other antioxidants
Scurvy; Immune support; Wound healing; Cardiovascular disease; Cancer adjunct; Iron deficiency
Antioxidant (fat and water-soluble); chelates heavy metals; supports mitochondrial function, glucose metabolism
Diabetic neuropathy; Heavy metal detoxification; Liver disease; Neuropathy; Cognitive decline
Adaptogen; reduces cortisol, modulates GABA, supports thyroid, neuroprotective via withanolides
Anxiety; Stress; Hypothyroidism; Insomnia; Fatigue; Low testosterone; Cognitive decline
Activates AMPK; improves insulin sensitivity, modulates gut microbiome, antimicrobial
Type 2 diabetes; PCOS; Metabolic syndrome; Hyperlipidemia; SIBO; Hypertension
Choline + cytidine; increases acetylcholine and phosphatidylcholine, supports brain energy, neuroprotection, focus
Cognitive decline; Memory impairment; Stroke recovery; ADHD; Glaucoma; Brain fog
Increases phosphocreatine stores; rapid ATP regeneration, enhances strength, power, muscle mass, cognitive function
Athletic performance; Muscle building; Strength; Cognitive performance; Neurological disease; Vegetarian
Omega-3 structural component of brain/retina; neuroprotective, supports cognitive development, vision, mood
Cognitive decline; ADHD; Depression; Pregnancy/lactation; Dry eyes; Macular degeneration
Increases alpha brain waves, modulates GABA/dopamine/serotonin; promotes relaxation without sedation
Anxiety; Stress; ADHD; Insomnia; High blood pressure
Live beneficial bacteria that restore gut microbiome balance, support immune function, produce SCFAs
Dysbiosis; IBS; IBD; Diarrhea; Antibiotic recovery; Immune support; Mood disorders
Activates Nrf2 pathway; powerful antioxidant, detoxification, anti-cancer, anti-inflammatory, neuroprotective
Cancer prevention; Detoxification; Autism; Inflammation; H. pylori; Liver support
Cofactor for 100+ enzymatic reactions including neurotransmitter synthesis, homocysteine metabolism
PMS; Nausea; Carpal tunnel; Depression; High homocysteine; Morning sickness
Activates proteins (osteocalcin, MGP) that direct calcium into bones and away from arteries
Osteoporosis; Arterial calcification; Cardiovascular disease; Tooth decay
Essential for immune function, wound healing, DNA synthesis, taste/smell, testosterone production
Immune deficiency; Wound healing; Acne; Low testosterone; Taste/smell loss; Hair loss
Choline source crossing BBB; increases acetylcholine, supports memory, focus, neuroprotection, growth hormone release
Cognitive decline; Memory impairment; Alzheimer's; ADHD; Stroke recovery; Athletic performance
Carotenoid antioxidant (6000x stronger than vitamin C); anti-inflammatory, neuroprotective, supports eye/skin/joint health
Eye strain; Macular degeneration; Skin aging (UV protection); Joint pain; Athletic recovery; Brain health
Enhances neurotransmitter function, antioxidant, neuroprotective, supports memory consolidation, reduces anxiety
Memory impairment; Cognitive decline; Anxiety; ADHD; Alzheimer's prevention; Learning
Structural protein providing amino acids (glycine, proline, hydroxyproline) for skin, joints, gut, bones
Joint pain; Skin aging; Wrinkles; Gut health; Bone health; Wound healing; Hair/nails
Anti-inflammatory (COX-2 inhibition), anti-nausea, digestive support, antioxidant, circulatory support
Nausea; Morning sickness; Motion sickness; Osteoarthritis; Inflammation; Digestive upset
Master antioxidant; detoxifies xenobiotics via conjugation; recycles vitamins C/E; supports immune and liver function
Detoxification; Liver disease; Oxidative stress; Parkinson's; Chronic illness; Immune support
Catechin antioxidants (EGCG); supports metabolism, fat burning, cardiovascular health, neuroprotection, anti-cancer
Weight management; Cardiovascular disease; Cancer prevention; Cognitive health; Metabolic syndrome
Essential for hemoglobin, oxygen transport, energy production, immune function, cognitive health
Iron deficiency anemia; Fatigue; Restless leg syndrome; Hair loss; Poor concentration
Primary fuel for enterocytes and immune cells; supports gut lining integrity, reduces intestinal permeability
Leaky gut; IBS; IBD; Muscle wasting; Post-workout recovery; Immune support
Neuroprotective via NGF (nerve growth factor) stimulation; supports cognitive function, gut health
Cognitive decline; Alzheimer's; Depression; Anxiety; Neuropathy; Gut health (IBD)
Citric acid chelate with good absorption; has mild laxative effect due to osmotic action in gut
Constipation; Migraines; Muscle cramps; General magnesium deficiency
Circadian rhythm regulator; supports sleep onset, antioxidant, immune support, neuroprotective
Insomnia; Jet lag; Shift work; Delayed sleep phase; Immune support; Migraines; Aging
Hepatoprotective via silymarin (antioxidant, promotes glutathione, stabilizes hepatocyte membranes)
Fatty liver; Cirrhosis; Hepatitis; Liver detoxification; Mushroom poisoning (emergency)
Senolytic (clears senescent cells), antioxidant, anti-inflammatory, antiviral, supports mitochondria
Aging; Allergies; Inflammation; Viral infections; Cardiovascular disease; Senescent cell clearance
Beneficial yeast that supports gut health, resists antibiotics, produces anti-inflammatory factors
Antibiotic-associated diarrhea; C. diff infection; Traveler's diarrhea; IBD; IBS
Essential for glutathione peroxidase and thyroid hormone metabolism; antioxidant and immune support
Thyroid disorders; Immune deficiency; Cancer prevention; Fertility; Cardiovascular disease
Essential cofactor for carbohydrate metabolism and ATP production; supports nerve function
Beriberi; Wernicke-Korsakoff syndrome; Neuropathy; Fatigue; Heart failure
Zinc + L-carnosine chelate; supports gut lining integrity, reduces inflammation, wound healing, H. pylori treatment
Leaky gut; Gastritis; Ulcers; H. pylori; IBD; NSAID damage; Gut repair
Shiitake mushroom extract; immune modulation, enhances NK cell activity, supports liver, anti-viral
Immune support; HPV; Cancer adjunct; Liver health; Viral infections; Chemotherapy side effects
Anti-inflammatory via 5-LOX inhibition (reduces leukotrienes); supports joint, gut, respiratory health
Osteoarthritis; Rheumatoid arthritis; Asthma; IBD; Colitis; Inflammation
Enhances insulin signaling and glucose uptake; supports macronutrient metabolism
Type 2 diabetes; Insulin resistance; PCOS; Hypoglycemia; Weight management
Rich in immunoglobulins (IgG), growth factors, lactoferrin; repairs gut lining, supports immunity
Leaky gut; Immune support; Athletic recovery; Diarrhea; Gut infections; Anti-aging
Licorice without glycyrrhizin; soothes mucosa, increases mucus production, anti-inflammatory, supports gut lining
Heartburn; GERD; Gastritis; Ulcers; Leaky gut; IBS; Sore throat
Promotes healthy estrogen metabolism (2-hydroxy pathway), supports estrogen detoxification
Estrogen dominance; PMS; PCOS; Breast health; Prostate health; Acne
Antiviral, immune support, anti-inflammatory via anthocyanins; reduces cold/flu duration and severity
Cold; Flu; Immune support; Upper respiratory infections; Sinusitis
Increases blood flow (especially cerebral), antioxidant, neuroprotective, anti-platelet, supports cognition
Cognitive decline; Memory impairment; Dementia; Tinnitus; Peripheral artery disease; Anxiety
Cardiotonic; dilates coronary vessels, positive inotropic effect, antioxidant, supports heart function and circulation
Heart failure; Angina; Hypertension; Arrhythmias; Atherosclerosis; Circulation
Converts to L-arginine more efficiently; increases nitric oxide, improves blood flow, reduces fatigue
Erectile dysfunction; Athletic performance; Hypertension; Muscle fatigue; Cardiovascular health
Carotenoid antioxidant concentrated in macula; protects eyes from blue light, supports vision, cognitive health
Macular degeneration; Cataracts; Eye strain; Blue light exposure; Cognitive decline
Insulin sensitizer; supports ovarian function, mood, neurotransmitter signaling, cellular signaling
PCOS; Insulin resistance; Infertility; Anxiety; Depression; Metabolic syndrome; Gestational diabetes
Phospholipid in brain cell membranes; supports memory, cognition, mood, reduces cortisol, neuroprotective
Cognitive decline; Memory impairment; ADHD; Depression; High cortisol; Alzheimer's prevention
Non-digestible fibers that feed beneficial gut bacteria; increase SCFA production
Constipation; Dysbiosis; Gut health; Blood sugar management; Cholesterol; Calcium absorption
Polyphenol activating sirtuins (SIRT1); antioxidant, anti-inflammatory, cardioprotective, mimics caloric restriction
Cardiovascular disease; Aging; Cognitive decline; Cancer prevention; Metabolic syndrome
Adaptogen; enhances mental performance, reduces fatigue, modulates stress response via HPA axis
Fatigue; Depression; Stress; Cognitive performance; Altitude sickness; Athletic performance
Regulates calcium, supports mitochondrial function, bile salt formation, osmoregulation, neuromodulation
Heart failure; Hypertension; Diabetes; Metabolic syndrome; Fatty liver; Athletic performance
Immune modulation via PSK/PSP (polysaccharide-K/peptide); supports gut microbiome, cancer adjunct
Immune support; Cancer adjunct (especially with chemo); HPV; Gut health
Cofactor for FAD/FMN in energy production and antioxidant recycling; supports mitochondrial function
Migraine prevention; Cataracts; Anemia; Mitochondrial disorders
Flavonoid; anti-inflammatory, anxiolytic, neuroprotective, senolytic, supports sleep, CD38 inhibitor (boosts NAD+)
Anxiety; Insomnia; Inflammation; Aging; Cancer prevention; NAD+ support
Polysaccharide immune modulator; activates macrophages, NK cells, supports cholesterol, wound healing
Immune support; High cholesterol; Wound healing; Cancer adjunct; Infections
Short-chain fatty acid that fuels colonocytes, reduces inflammation, supports gut barrier integrity
IBD; Leaky gut; IBS; Colitis; Insulin resistance; Neuroinflammation
Essential for bone health, muscle contraction, nerve signaling, blood clotting, cellular signaling
Osteoporosis; Osteopenia; Muscle cramps; Hypertension; PMS; Hypocalcemia
Supplement pancreatic enzymes (amylase, protease, lipase) to aid macronutrient digestion
Bloating; Gas; Indigestion; Pancreatic insufficiency; IBS; Food sensitivities
Building block of cartilage glycosaminoglycans; supports joint lubrication, cartilage repair, reduces inflammation
Osteoarthritis; Joint pain; Cartilage degradation; TMJ; Sports injuries
Inhibitory neurotransmitter; collagen component; supports sleep, detoxification (glutathione), and methylation
Insomnia; Sleep quality; Schizophrenia; Detoxification; Joint health
Holds 1000x its weight in water; lubricates joints, hydrates skin, supports eye health, wound healing
Joint pain; Dry skin; Wrinkles; Dry eyes; Wound healing; TMJ
EPA/DHA in phospholipid form (better absorption) plus astaxanthin; anti-inflammatory, neuroprotective
Cardiovascular disease; Inflammation; PMS; Arthritis; Cognitive health; Dry eyes
Malic acid supports mitochondrial ATP production; beneficial for energy and muscle function
Fibromyalgia; Chronic fatigue; Muscle pain; Low energy
Fibrinolytic enzyme from natto; breaks down fibrin, supports blood flow, cardiovascular health, clot prevention
Cardiovascular disease; Thrombosis prevention; Hypertension; Poor circulation; Blood clots
NAD+ precursor; supports mitochondrial biogenesis, DNA repair, sirtuins, neuroprotection
Aging; Cognitive decline; Mitochondrial dysfunction; Metabolic syndrome; Neurodegenerative disease
Adaptogen; modulates HPA axis, enhances energy, cognitive performance, immune support, anti-inflammatory
Fatigue; Erectile dysfunction; Cognitive performance; Immune support; Diabetes; Stress
Mitochondrial biogenesis stimulator, antioxidant, neuroprotective; supports new mitochondria formation
Cognitive decline; Mitochondrial dysfunction; Fatigue; Neuroprotection; Energy
Immune modulation, anti-inflammatory, adaptogen via polysaccharides and triterpenes; supports liver and longevity
Immune support; Stress; Insomnia; Liver health; Cancer adjunct; Longevity
Universal methyl donor; supports methylation, neurotransmitter synthesis, liver detoxification, joint health
Depression; Osteoarthritis; Liver disease; Fibromyalgia; Methylation support
Spore-forming probiotics (Bacillus species); survive stomach acid, support gut diversity, immune modulation
Dysbiosis; IBS; IBD; SIBO; Leaky gut; Immune support; Antibiotic recovery
Nutrient-dense algae with protein, antioxidants, phycocyanin; supports detoxification, immune, and anti-inflammatory
Heavy metal detoxification; Malnutrition; Allergies; Immune support; Oxidative stress
NAD+ precursor essential for energy metabolism, DNA repair, and sirtuins; niacin improves lipid profiles
High cholesterol; Pellagra; Insulin resistance; Skin aging; Cognitive decline
Carotenoid antioxidant in macula and lens; filters blue light, protects retina, synergistic with lutein
Macular degeneration; Cataracts; Eye strain; Blue light exposure; Vision health
Direct serotonin precursor (crosses BBB); supports mood, sleep, appetite regulation
Depression; Insomnia; Anxiety; Fibromyalgia; Appetite suppression; Migraines
Soothes mucosa, anti-inflammatory, supports gut healing, prebiotic, immunomodulatory
IBS; IBD; Leaky gut; Gastritis; Constipation; Skin healing (topical)
Supplements stomach acid and pepsin to improve protein digestion and nutrient absorption
Low stomach acid (hypochlorhydria); GERD (paradoxical); Bloating; SIBO; B12/iron deficiency
Anti-inflammatory, antioxidant, immunomodulatory via thymoquinone; supports metabolic and respiratory health
Asthma; Allergies; Hypertension; Diabetes; Metabolic syndrome; Autoimmune disease
Binds heavy metals (mercury, lead, cadmium), supports detoxification, nutrient-dense algae
Heavy metal detoxification; Mercury chelation; Nutrient deficiency; Immune support
Cartilage component; attracts water into cartilage, inhibits cartilage-degrading enzymes, anti-inflammatory
Osteoarthritis; Joint pain; Cartilage health; Sports injuries
Increases ATP production, improves oxygen utilization, adaptogen; supports energy and athletic performance
Fatigue; Low libido; Athletic performance; Chronic kidney disease; Respiratory health
Insulin sensitizer; supports insulin signaling, androgen metabolism, ovarian function
PCOS; Insulin resistance; Infertility; Hirsutism; Metabolic syndrome
5-carbon sugar for ATP synthesis; rapidly restores cellular energy, supports heart, muscles, recovery
Chronic fatigue; Fibromyalgia; Heart failure; Muscle recovery; Mitochondrial dysfunction
Immune stimulant, anti-inflammatory; enhances phagocytosis, increases white blood cell activity, antiviral
Cold; Flu; Upper respiratory infections; Immune support; Wound healing
Senolytic (clears senescent cells), neuroprotective, anti-inflammatory, supports brain health and longevity
Aging; Cognitive decline; Neurodegenerative disease; Inflammation; Senescent cell clearance
Omega-6 that converts to anti-inflammatory DGLA; supports skin, hormonal balance, inflammation
Eczema; PMS; Rheumatoid arthritis; Diabetic neuropathy; Dry skin; ADHD
Adaptogen; anti-inflammatory, antioxidant, modulates cortisol and blood sugar via ursolic/oleanolic acids
Stress; Anxiety; Diabetes; Metabolic syndrome; Respiratory infections; Inflammation
Estrogen modulator; converts to DIM in stomach; supports healthy estrogen metabolism and cell cycle regulation
Estrogen dominance; Breast cancer prevention; Cervical dysplasia; PCOS; Fibrocystic breasts
Nitric oxide precursor; supports vasodilation, blood flow, wound healing, immune function, growth hormone release
Erectile dysfunction; Cardiovascular disease; Wound healing; Athletic performance; Angina; Hypertension
Transports fatty acids into mitochondria for beta-oxidation; supports energy, athletic performance, cardiovascular health
Fatigue; Heart failure; Angina; Infertility; PCOS; Athletic performance; Fat loss
Carotenoid antioxidant; supports prostate health, cardiovascular health, skin protection, anti-cancer
Prostate health; BPH; Cardiovascular disease; Skin aging (UV protection); Cancer prevention
Crosses blood-brain barrier effectively; supports cognitive function, memory, neuroplasticity
Cognitive decline; Memory impairment; Brain fog; ADHD; Traumatic brain injury
Organic sulfur; anti-inflammatory, supports collagen/keratin production, antioxidant, reduces joint pain
Osteoarthritis; Joint pain; Allergies; Skin health; Hair/nail health; Inflammation
NAD+ precursor; supports mitochondrial function, DNA repair, sirtuins, energy production, anti-aging
Aging; Fatigue; Cognitive decline; Metabolic syndrome; Cardiovascular health
Resveratrol analog (better bioavailability); sirtuin activator, antioxidant, anti-inflammatory, cognitive support
Aging; Cognitive decline; Cardiovascular disease; Diabetes; Inflammation; Cancer prevention
5-alpha-reductase inhibitor; reduces DHT conversion, supports prostate health, anti-androgenic, anti-inflammatory
BPH (benign prostatic hyperplasia); Prostate health; Hair loss (androgenic alopecia); Hirsutism
Mucilaginous herb; coats and soothes mucous membranes, anti-inflammatory, supports gut lining, prebiotic
GERD; Gastritis; IBS; IBD; Leaky gut; Sore throat; Diarrhea; Constipation
Methyl donor; lowers homocysteine, supports methylation, liver function, athletic performance
High homocysteine; Fatty liver; Methylation support; Athletic performance; Cardiovascular disease
Supports vision, immune function, cell differentiation, and skin health through retinoid receptor activation
Night blindness; Dry skin; Immune deficiency; Acne
Immune stimulant, anti-inflammatory, antiviral; supports upper respiratory health
Common cold; Flu; Sinusitis; Immune support; Upper respiratory infections
Choleretic (stimulates bile production), hepatoprotective, antioxidant, supports digestion and lipid metabolism
Dyspepsia; High cholesterol; Liver support; IBS; Gallbladder support; Detoxification
Immune modulator, adaptogen; enhances NK cell activity, anti-inflammatory, antiviral
Immune support; Chronic fatigue; Chemotherapy side effects; Heart failure; Kidney disease
Carnosine precursor; buffers muscle pH (lactic acid), delays fatigue, enhances high-intensity performance
Athletic performance; Muscle endurance; High-intensity exercise; Fatigue
Dipeptide antioxidant; anti-glycation (prevents AGEs), neuroprotective, supports muscle, longevity, wound healing
Aging; Diabetes (glycation); Cognitive decline; Cataracts; Wound healing; Athletic performance
Antioxidant (high ORAC), anti-inflammatory, immune modulation via polysaccharides; adaptogen
Immune support; Inflammation; Cancer prevention; Oxidative stress; Gut health
Essential for thyroid hormone synthesis (T3/T4); supports breast and prostate health, immune function
Hypothyroidism; Goiter; Fibrocystic breast; Cognitive impairment; Iodine deficiency
Essential amino acid; supports collagen synthesis, calcium absorption, immune function, inhibits herpes replication
Herpes simplex; Cold sores; Osteoporosis; Anxiety; Athletic recovery; Wound healing
Serotonin and melatonin precursor; supports mood, sleep, and appetite regulation
Depression; Insomnia; Anxiety; PMS; Appetite control
Precursor to dopamine, norepinephrine, epinephrine, thyroid hormones; supports focus, stress resilience, mood
ADHD; Depression; Stress; Fatigue; Hypothyroidism; Cognitive performance
Mucilaginous herb; coats mucous membranes, anti-inflammatory, soothes gut lining, supports respiratory tract
Gastritis; GERD; IBS; Leaky gut; Cough; Sore throat; Dry cough; Urinary tract irritation
Rapid energy source; converts to ketones, supports ketogenesis, brain energy, fat burning, gut health
Ketogenic diet; Cognitive performance; Weight management; Energy; Malabsorption; Alzheimer's support
Binds heavy metals (lead, mercury, arsenic) without depleting essential minerals; inhibits galectin-3
Heavy metal detoxification; Cancer metastasis prevention; Cardiovascular health (galectin-3)
Major phospholipid in cell membranes; supports liver function, brain health, fat metabolism, choline source
Fatty liver; Cognitive decline; High cholesterol; Liver disease; Gallbladder support
Essential electrolyte; regulates fluid balance, nerve signals, muscle contractions, blood pressure, pH balance
Hypertension; Muscle cramps; Hypokalemia; Kidney stones; Alkalinization
Adaptogen; supports liver detoxification, antioxidant, enhances mental performance, normalizes stress response
Stress; Fatigue; Liver health; Athletic performance; Cognitive performance; Depression
Proteolytic enzyme; breaks down non-living tissue, reduces inflammation, mucus, supports healing, pain relief
Inflammation; Sinusitis; Chronic pain; Post-surgery recovery; Arterial plaque; Cysts; Fibroids
Fulvic acid + minerals; mitochondrial support, enhances CoQ10, testosterone support, adaptogen, antioxidant
Fatigue; Low testosterone; Cognitive decline; Aging; Mitochondrial dysfunction; Athletic performance
Induces autophagy (cellular cleaning), supports longevity, cardioprotective, cognitive health
Aging; Cardiovascular disease; Cognitive decline; Longevity; Autophagy induction
Cofactor for CoA synthesis essential for fatty acid metabolism, steroid hormone production
Adrenal fatigue; Acne; Wound healing; High cholesterol; Stress
Lipid-soluble antioxidant protecting cell membranes from oxidative damage; supports cardiovascular and immune health
Cardiovascular disease; Neuropathy; Infertility; Immune support; Alzheimer's prevention
Modulates prolactin via dopamine receptors; balances progesterone:estrogen ratio
PMS; PMDD; Irregular cycles; Infertility; Perimenopause; Acne (hormonal)
Anti-inflammatory, antihistamine; binds SHBG (increases free testosterone), supports prostate, joint, and allergy relief
BPH; Allergies; Hay fever; Arthritis; Urinary health; Joint pain
Leucine, isoleucine, valine; stimulate muscle protein synthesis, reduce muscle breakdown, support recovery
Muscle recovery; Athletic performance; Muscle wasting; Liver disease; Fatigue
Supports bone health, hormone metabolism (increases free testosterone, activates vitamin D), reduces inflammation
Osteoporosis; Arthritis; Low testosterone; Cognitive function; Vitamin D optimization
Inhibits beta-glucuronidase (enhances phase 2 detoxification); supports estrogen and toxin elimination
Estrogen dominance; Detoxification; High estrogen; Cancer prevention; Liver support
Anti-inflammatory via NF-κB inhibition, immune modulation, antiviral, antioxidant
Arthritis; Viral infections; Immune support; Lyme disease; Leaky gut; Inflammation
Choleretic (stimulates bile), diuretic, prebiotic, liver and kidney support
Liver support; Edema; Constipation; Detoxification; Digestive health; Bloating
Primary inhibitory neurotransmitter; promotes relaxation, reduces anxiety, supports sleep (limited BBB crossing)
Anxiety; Insomnia; Stress; High blood pressure; Muscle tension
Structural component of collagen (1/3 of collagen is proline); supports skin, joints, gut lining, wound healing
Joint health; Skin aging; Wound healing; Gut repair; Osteoarthritis
Trace mineral; neuroprotective, supports mood stability, brain health, increases BDNF, GSK-3β inhibition
Mood disorders; Depression; Anxiety; Brain health; Cognitive decline; Neuroprotection
Fibrinolytic enzyme from earthworms; potent blood thinner, dissolves fibrin, supports cardiovascular health
Cardiovascular disease; Thrombosis; Blood clots; Stroke prevention; Poor circulation
Adaptogen supporting HPA axis; enhances libido, energy, and hormonal balance without altering hormone levels directly
Low libido; Erectile dysfunction; Fatigue; Menopause; Fertility; Depression
Provides bile salts; supports fat digestion and absorption, gallbladder support, detoxification
Gallbladder removal; Fat malabsorption; Constipation; Bile insufficiency; Fat-soluble vitamin deficiency
Balances estrogen, supports endometrial health, calming effect via GABA modulation; regulates menstrual cycle
Estrogen dominance; Insomnia; Anxiety; PMS; Perimenopause; Menopause; Endometriosis
DHEA metabolite that does NOT convert to sex hormones; supports metabolism, thermogenesis, immune function, weight loss
Weight management; Metabolic slowdown; Low energy; Immune support; Aging (without hormonal effects)
Blood purifier, prebiotic (inulin), supports liver detoxification, anti-inflammatory
Skin conditions (acne, eczema); Liver support; Detoxification; Gut health; Inflammation
Mobilizes heavy metals (especially mercury) from tissues; supports detoxification
Heavy metal detoxification; Mercury chelation (pair with binder)
Component of enzymes (SOD, ceruloplasmin) essential for iron metabolism, energy production, connective tissue
Anemia (iron-refractory); Osteoporosis; Cardiovascular disease; Immune dysfunction
Precursor to testosterone and estrogen; supports energy, libido, immune function, anti-aging
Adrenal insufficiency; Low testosterone; Menopause; Depression; Osteoporosis; Aging
Leucine metabolite; reduces muscle breakdown, enhances muscle protein synthesis, supports recovery
Muscle wasting; Sarcopenia; Athletic performance; Post-surgery recovery; Aging
Phytic acid derivative; chelates iron (anti-cancer), antioxidant, immune support, prevents kidney stones
Cancer prevention; Kidney stones; High iron; Immune support; Antioxidant support
Antimicrobial (carvacrol/thymol); antibacterial, antifungal, antiviral, antiparasitic
SIBO; Candida; Respiratory infections; Gut dysbiosis; Parasites; Food poisoning
Increases osteoblast activity (bone formation) and decreases osteoclast activity (bone breakdown); similar to calcium
Osteoporosis; Osteopenia; Bone fracture prevention; Tooth remineralization
Cofactor for carboxylases in fatty acid synthesis, gluconeogenesis, amino acid catabolism; supports hair/nail health
Hair loss; Brittle nails; Dermatitis; Diabetes; Multiple sclerosis
Binds toxins, heavy metals, mycotoxins via adsorption; supports detoxification, gut cleansing
Detoxification; Mold toxicity; Heavy metals; Gut toxins; Food poisoning; IBS
Alters fat metabolism, reduces fat storage, increases lean mass via PPARγ modulation
Weight management; Body composition; Metabolic syndrome; Cancer prevention
Cofactor for SOD, bone formation, wound healing, carbohydrate metabolism
Osteoporosis; Diabetes; Epilepsy; Wound healing; Mitochondrial support
Antimicrobial, antifungal, anti-inflammatory via lapachol and beta-lapachone; supports immune health
Candida; Fungal infections; Immune support; Inflammation; Cancer adjunct
"Mother hormone" precursor to all steroid hormones (DHEA, progesterone, testosterone, estrogen, cortisol)
Memory decline; Fatigue; Low hormone levels; Mood disorders; Stress
Supports collagen and connective tissue formation; promotes bone, hair, skin, and nail health
Osteoporosis; Hair loss; Brittle nails; Skin aging; Joint health
May increase LH and support testosterone production; supports libido, athletic performance, urinary health
Low libido; Erectile dysfunction; Athletic performance; Infertility; Urinary tract health
Volcanic mineral that binds heavy metals, toxins, ammonia via ion exchange; supports detoxification
Heavy metal detoxification; Mold toxicity; Ammonia; Gut detoxification
Binds toxins, drugs, heavy metals via adsorption in GI tract; prevents absorption
Acute poisoning; Gas; Bloating; Detoxification; Food poisoning; Mold toxicity
Mild PDE5 inhibitor (icariin); supports blood flow, libido, testosterone, bone health, neuroprotection
Erectile dysfunction; Low libido; Osteoporosis; Fatigue; Cognitive decline
Cofactor for enzymes that metabolize sulfites, purines, aldehydes; supports detoxification
Sulfite sensitivity; Gout; Detoxification support; Aldehyde toxicity
Insulin-mimetic; enhances insulin sensitivity, glucose uptake, supports blood sugar management
Type 2 diabetes; Insulin resistance; Blood sugar management; Athletic performance