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Adaptogen; reduces cortisol, modulates GABA, supports thyroid, neuroprotective via withanolides
300-600mg/day (KSM-66 or Sensoril®)
KSM-66 (full-spectrum root), Sensoril® (root+leaf), withanolide standardized extracts
Works synergistically with:
Root traditionally used in Ayurveda (not a food)
May potentiate sedatives, thyroid meds, immunosuppressants
Hyperthyroidism; Pregnancy; Autoimmune disease (caution)
KSM-66 most studied; reduces cortisol significantly; supports thyroid; may increase testosterone; avoid in hyperthyroidism
This information is for educational purposes. Always consult with a qualified healthcare provider before starting any new supplement protocol.
Anti-inflammatory via COX/LOX inhibition and NF-κB modulation; antioxidant, neuroprotective
Activates AMPK; improves insulin sensitivity, modulates gut microbiome, antimicrobial
Hepatoprotective via silymarin (antioxidant, promotes glutathione, stabilizes hepatocyte membranes)