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Check for interactions between drugs, supplements, herbs, and foods. Identify dangerous combinations and beneficial synergies.
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The most common and clinically significant interactions
Increased bleeding risk
Both thin the blood through different mechanisms. Combined use can significantly increase bleeding risk. Monitor INR closely.
Blocks absorption
Calcium, iron, and magnesium bind to thyroid medication in the gut, reducing absorption by up to 40%. Take thyroid meds 4 hours apart.
Serotonin syndrome risk
Both increase serotonin levels. Combined use can trigger serotonin syndrome — a potentially life-threatening condition with agitation, rapid heart rate, and high temperature.
Essential synergy
Magnesium is required to convert vitamin D into its active form. Without adequate magnesium, vitamin D supplementation may be ineffective. Take together.
2,000% absorption boost
Piperine in black pepper inhibits glucuronidation of curcumin, increasing bioavailability by up to 2,000%. Always pair turmeric supplements with piperine.
Severe hypotension risk
NAC potentiates the vasodilatory effects of nitroglycerin, potentially causing dangerous drops in blood pressure. Avoid combining without medical supervision.
Depletion risk at high doses
High-dose zinc (50mg+) competes with copper for absorption, potentially causing copper deficiency over time. Supplement copper at a 15:1 zinc-to-copper ratio.
Calcium targeting synergy
Vitamin D increases calcium absorption while K2 activates proteins that direct calcium into bones instead of arteries. Together they prevent soft tissue calcification.