TMG (Trimethylglycine/Betaine)

Mechanism of Action

Methyl donor; lowers homocysteine, supports methylation, liver function, athletic performance

Primary Applications

High homocysteine

Fatty liver

Methylation support

Athletic performance

Cardiovascular disease

Recommended Dosage

500-3000mg/day

Available Forms

Betaine anhydrous, trimethylglycine

Top Brands

ThornePure EncapsulationsJarrowNOW

Synergies

Works synergistically with:

B-vitamins (methylation)

SAMe

Methylfolate

B12

Natural Food Sources

Beets; Spinach; Quinoa; Whole grains

Interactions

May increase SAMe levels; May affect homocysteine metabolism

Contraindications

None at therapeutic doses

Clinical Notes

From beets; methyl donor; lowers homocysteine; supports liver and methylation; cheaper alternative to SAMe for methylation

Quick Overview

CategoryAmino Acids

GBS Score78/100

IDAA018

Key Points

Evidence-based dosing

Mechanism documented

Interaction screening

Synergy optimization

Get This Supplement

Professional-grade from Fullscript

This information is for educational purposes. Always consult with a qualified healthcare provider before starting any new supplement protocol.

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