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Prolotherapy (proliferative therapy) involves injecting a mild irritant solution (typically dextrose) into damaged ligaments, tendons, or joints to trigger the body's natural healing cascade. Unlike cortisone injections that suppress inflammation, prolotherapy intentionally creates controlled micro-inflammation that stimulates collagen production, tissue strengthening, and structural repair.
The injected solution causes localized inflammation that attracts growth factors, fibroblasts, and healing cells to the area. Over weeks to months, new collagen fibers form and tighten, stabilizing loose joints and strengthening damaged connective tissue. The result is long-term structural improvement rather than temporary symptom relief.
Prolotherapy is particularly effective for chronic joint instability, ligament laxity, tendon tears, and arthritis. Developed by Dr. George Hackett in the 1950s, it has been refined over decades and is now used by integrative physicians, orthopedists, and sports medicine practitioners worldwide.
Prolotherapy has been studied for over 70 years with research supporting its use for chronic musculoskeletal pain, particularly low back pain and osteoarthritis. Systematic reviews show positive outcomes for joint pain and function. When performed by trained physicians, it's very safe. Risks include temporary pain increase, rare infection, or nerve irritation. Much safer than surgery with comparable or better long-term outcomes for appropriate conditions.
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