40Hz Gamma Entrainment Therapy

40Hz Gamma Entrainment Therapy uses precisely calibrated sound and light flickering at 40 cycles per second to entrain your brain's gamma oscillations, the neural frequency associated with peak cognition, memory consolidation, and cellular maintenance. Pioneered by MIT's Li-Huei Tsai at the Picower Institute, this therapy activates your brain's built-in cleanup crew: microglia that clear amyloid plaques, tau tangles, and cellular debris that accumulate with age and disease.

The mechanism is elegant. When neurons fire in synchronized 40Hz patterns, they trigger a cascade of protective responses: microglia shift from inflammatory to phagocytic mode (actively eating debris), astrocytes improve waste clearance via the glymphatic system, oligodendrocytes repair damaged myelin sheaths, and blood vessel function improves throughout the brain. One hour of daily stimulation has been shown to increase amyloid clearance from cerebrospinal fluid by 200% in primate studies.

Phase II clinical trials in Alzheimer's patients demonstrated slowed brain atrophy, preserved white matter integrity, and measurable cognitive improvements. The Cognito Therapeutics GENUS device is now in Phase III nationwide trials. But the implications extend far beyond Alzheimer's: 40Hz stimulation shows promise for Parkinson's, stroke recovery, traumatic brain injury, epilepsy, and general cognitive enhancement. This may be the first truly non-invasive therapy that reverses brain aging at the cellular level.