ModerateGBS: 79 (Moderate-High Risk)autoimmune

LDN (Low-Dose Naltrexone)

Developer: Bernard Bihari

Ongoing, improvements typically in 2-3 months

Protocol Overview

Off-label use of low-dose naltrexone (1.5-4.5mg) to modulate immune system and increase endorphins. Originally an opioid antagonist at high dose (50mg), low dose has paradoxical immune-boosting effects.

Conditions Treated

Multiple sclerosis

Crohn's disease

Hashimoto's

rheumatoid arthritis

fibromyalgia

cancer

Protocol Steps

Obtain prescription from LDN-friendly physician (off-label, requires compounding pharmacy)

Start low: 1.5mg at bedtime for 2 weeks

Increase gradually: 3mg for 2 weeks, then 4.5mg (standard dose)

Take at bedtime on empty stomach (some prefer morning if it causes vivid dreams/insomnia)

Must be compounded as immediate-release (no fillers like lactose for sensitive patients)

Continue daily - consistency is key

Monitor symptoms - improvements typically gradual over 2-3 months

Some patients find sweet spot at 3mg or 4.5mg - adjust based on response

Can combine with other treatments (not with opioid medications)

Generally continue long-term as benefits typically require ongoing use

Key Resources

LDN Research Trust (ldnresearchtrust.org), "The LDN Book" edited by Linda Elsegood, research papers by Bihari, compounding pharmacy directory

Contraindications & Risks

Cannot use with opioid medications (blocks effect), Crohn's with obstruction (temporary inflammation), pregnancy uncertain

Important Notes

Strong safety profile, inexpensive ($30-50/month), growing evidence base. Works by blocking opioid receptors temporarily, causing rebound endorphin increase and immune modulation. Many physicians now prescribe. Need compounding pharmacy. Off-label but increasingly accepted.

Also Effective For

Multiple Sclerosis Crohn's Disease / Ulcerative Colitis (IBD)Hashimoto's Thyroiditis Rheumatoid Arthritis Chronic Fatigue / Fibromyalgia Cancer (Integrative Support)

Critical Safety Warning

This protocol is documented for educational purposes only. The Gabriel Bullshit Score (GBS) of 79 reflects significant institutional response and controversy. Some alternative health protocols have resulted in serious harm or death.

Always consult with qualified healthcare professionals before beginning any treatment. Do not delay or forego proven medical care.

Quick Overview

Evidence LevelModerate

GBS Score79 / 100

Categoryautoimmune

DeveloperBernard Bihari

DurationOngoing, improvements typically in 2-3 months

About GBS Score

The Gabriel Bullshit Score reflects the magnitude of institutional response, controversy, and documented concerns. Higher scores indicate greater institutional pushback, not necessarily inefficacy. This is a research tool, not medical advice.